Casanova F, et al. - This study investigated if disease duration or pre-existing macrovascular complications attenuated the link between hyperglycaemia and microvascular function in patients with type 2 diabetes (T2DM), cardiovascular disease (CVD), both or neither. Findings demonstrated an association of good glycaemic control with better microvascular function in patients with T2DM and CVD, whereas, this link was lost in those with prolonged disease. This indicates duration of diabetes may be a better surrogate for “advanced disease” than concomitant CVD, although this needs prospective validation.