Au A, et al. – This research was meant to study the causal associations of APOA5 (rs662799, rs3135506), APOB (rs693, rs1042031, rs1801701), APOC3 (rs4520, rs5128, rs2854116, rs2854117) and ABCA1 rs2230806 with ischemic stroke risk. Findings provided corroboration for a significant link between APOA5 rs662799 CC, APOA5 rs3135506 CG, APOB rs1801701 GA, APOB rs1042031 GA and ABCA1 rs2230806 GG with ischemic stroke risk.

Methods

• Researchers performed a systematic review to identify all the articles that were retrieved from multiple databases, up until March 2017.
• They extracted data from all eligible studies, and performed a meta-analysis using RevMan 5.3 and R package 3.2.1.
• The strength of association between each studied polymorphism and ischemic stroke risk was measured as odds ratios (ORs) and 95% confidence intervals (CIs), under fixed- and random-effect models.

Results

• Researchers identified a total of 79 studies reporting on the association between the studied polymorphisms and ischemic stroke risk.
• The pooled data suggested that all genetic models of APOA5 rs662799 (ORs = 1.23–1.43), allelic and over-dominant models of APOA5 rs3135506 (ORs = 1.77–1.97), APOB rs1801701 (ORs = 1.72–2.13) andAPOB rs1042031 (ORs = 1.66–1.88) as well as dominant model of ABCA1 rs2230806 (OR = 1.31) were significantly associated with higher risk of ischemic stroke.
• However, researchers observed no significant associations between ischemic stroke and the other five polymorphisms, namely ApoB (rs693) and APOC3 (rs4520, rs5128, rs2854116 and rs2854117), under any genetic model.