Thiesen DM, Koniker A, Gehrke T, et al. - Data from 33 persons were retrospectively obtained between September 2015 and May 2018 in order to examine the use of synovial α-defensin levels in recognizing periprosthetic joint infection (PJI) of the ankle. The sensitivity, specificity, and overall exactitude of the α-defensin test were 100%, 93.5%, and 93.9%, respectively. The positive and negative predictive value was 50% and 100%, respectively. To discover a late-onset PJI following total ankle arthroplasty, the α-defensin test appeared to be the best available synovial test. Although, additional prospective studies with a greater number of people are needed.