Xu Q, et al. - Experts evaluated the influence of age on oral squamous cell carcinoma patients and analyzed the reasons that may contribute to this difference. They enrolled 2,782 patients included 2,443 patients in a retrospective cohort and 339 patients in a prospective cohort to testify these findings. Older patients had worse prognosis, compared with young patients, and they noted its association with their more severe comorbidity and received more conservative treatment. Compared to the older patients, younger patients started smoking and drinking earlier and consumed more tobacco and alcohol.