Ferrari E, et al. - Researchers investigated 30-day and 1-year outcomes of patients undergoing transcatheter aortic valve implantation (TAVI) vs valve-in-valve (VinV) procedures for a failed bioprosthesis in Switzerland from the SwissTAVI Registry. They identified 4,599 and 157 consecutive patients who underwent TAVI in native aortic valves and VinV procedures in degenerate bioprosthesis, respectively, between February 2011 and December 2016. Compared with TAVI procedures, VinV aortic procedures had favorable 30-day and 1-year clinical outcomes for native aortic valve disease. They noted higher transvalvular mean gradients following VinV implants, however, this was not identified influencing the early clinical outcomes. While between the 2 groups all-cause mortality and cardiovascular mortality at 30 days was comparable, after 1 year, all-cause mortality was lower for VinV patients.