Pathela P, Jamison K, Blank S, et al. - As the PrEP program at New York City's Sexual Health Clinics affords intensive on-site navigation for linkage to PrEP care, researchers here appraised uptake of this intervention. Men who have sex with men (MSM) without HIV were classified hierarchically as having had (1) HIV postexposure prophylaxis (PEP) use (past year); or (2) selected sexually transmitted infections (STI) (past year); or (3) HIV-diagnosed sex/needle-sharing partners (past 6 months); or (4) expressed interest in PrEP (day of clinic visit). Navigation was accepted by 1,301 of 2106 PrEP (62%) patients. The lowest navigation acceptance levels (35%–46%) were observed among STI and PEP patients. Referrals were more frequently accepted by navigated MSM with PEP history, previous STI, or HIV-diagnosed partners than those with PrEP interest. They observed variation in the probability of linkage by insurance status; patient factors did not influence prescription. These findings suggest low navigation uptake among MSM in key priority groups (eg, previous STI), however, those who admitted navigation were likely to be referred for PrEP, implying a necessity for expanded up-front engagement.