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The histopathology of congenital hemangioma and its clinical correlations: A long‐term follow‐up study of 55 cases

Histopathology Apr 19, 2020

El Zein S, Boccara O, Soupre V, et al. - A long‐term follow‐up study of 55 cases was conducted to assess the the histopathology of congenital hemangioma and its clinical correlations. Researchers analyzed the histopathological features of 10 rapidly involuting (RICHs), 25 NICHs (noninvoluting) and 20 PICHs (partially involuting) described the patients’ long‐term clinical results, and tested clinicopathological correlations. There were no significant associations between the CH subtype, the histopathological pattern, and the time of the histopathological assessment. The study found unexpected intralobular expression of podoplanin in neonatal biopsies of five RICHs and PICHs. They found similar histopathological features in all three subtypes of CH, and were related to the time since disease onset; they recognize that RICH, PICH and NICH form a single entity and differ only in their involuting potential. The lobular architecture might lead to misdiagnosis of tufted hemangioma or Kaposiform hemangioendothelioma, along with the transient expression of intralobular podoplanin observed in some newborns’ specimens.

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