Jing W, Liu M., et al. - This post‐hoc analysis draws on data from the Global Burden of Disease Study 2017 to analyze global trends and regional differences in the incidence of hepatitis E virus (HEV) infection, in the hopes of creating global tailored prevention strategies. Annual HEV incident cases and incidence rates from 1990 to 2017 were gathered. Globally, HEV age‐standardized incidence rates were reduced by an average 0.16% per year, from 279.79 per 100,000 in 1990 to 269.70 per 100,000 in 2017, but the number of HEV incident cases rose by 17.63% from 16.53 million in 1990 to 19.44 million in 2017. An increasing trend was reported in Oceania and Western Europe, contrary to the global trend. In low and low‐middle SDI regions, the number of HEV incident cases increased remarkably between 1990 and 2017. In high SDI regions, the number of HEV incident cases increased by 4.63% mainly in 40 plus age group, with more than 40% of HEV incident cases in Western Europe in 2017 among those over 40 years old.