Mehrmal S, Uppal P, Nedley N, et al. - Since few current studies on the global incidence, prevalence, and burden of psoriasis disease are of high quality, making it difficult to find accurate data and comparisons, researchers analyzed global trends in psoriasis from 1990 to 2017 through the Global Burden of Disease Study database in 195 countries worldwide, including age-standardized prevalence rates, percent change in age-standardized prevalence rates, age and gender patterns, and psoriasis burden using disability adjusted life years. According to findings, In 2017, the age-specific prevalence rate showed a left-skewed distribution with a peak between 60 and 70 years of age, and an approximately equal male: female ratio across all ages. In high income and high sociodemographic index countries, psoriasis burden was greatest. The data presented in this work showed a positive linear link between psoriasis prevalence and comorbidities is seen with cardiovascular disease, mental health, T2DM, stroke, non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, non-melanoma skin cancer, and inflammatory bowel disease across all countries in 2017. There is an growing prevalence, burden, and related psoriasis comorbidities on a global scale, and the need for help to reduce this significant global health disparity.