The gentamicin-collagen implant and the risk of distant metastases of rectal cancer following short-course radiotherapy and curative resection: The long-term outcomes of a randomized study
International Journal of Colorectal Disease Jul 23, 2018
Rutkowski A, et al. - A previous study demonstrated that application of gentamicin-collagen implant (GCI) into the pelvic cavity after total mesorectal excision (TME) reduced the incidence of distant metastases, so researchers conducted a confirmatory study analyzing data of patients with rectal cancer. Eligibility criteria included adenocarcinoma of the rectum, preoperative short-term radiotherapy (5 × 5 Gy), and WHO performance score 0–1. The data showed the rate of distant metastases in patients after radical rectal cancer resection was significantly lessened after GCI application to the pelvic cavity.
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