Kamal S, et al. - In Egyptian patients with Gilbert syndrome (GS), an autosomal recessive inherited disorder of bilirubin glucuronidation, researchers studied the frequency, clinical course, genetic profile and health related quality of life [Short form-36 Health Survey version 2 (SF-36v2) and Chronic Liver Disease Questionnaire (CLDQ)]. In Egypt, Gilbert syndrome is a frequent inherited disorder. Other symptoms and nutritional deficiencies that lead to health related quality of life (HRQOL) impairment are related to jaundice episodes in a significant percentage of subjects with GS. For subjects with GS in the setting of anesthesia, pregnancy, treatment with direct antiviral therapy (DAAs), deliveries, surgery and weight loss plans, screening, counseling, monitoring and individualized health care are recommended. General anesthesia, pregnancy, fasting > 12 h, pregnancy, and low calorie weight losing plans, systemic infections and intensive physical effort were included risk factors for clinical jaundice.