The expression of special AT-rich binding protein 1 in cervical cancer and its clinical significance
OncoTargets and Therapy Feb 06, 2019
Zhao L, et al. - In cervical cancer patients, researchers examined the impact of special AT-rich binding protein 1 (SATB1) mRNA expression on tumor progression and outcomes. Analyzing a total of 33 cervical cancer patients treated in their hospital from September 2012 to December 2015, they identified significantly advanced International Federation of Gynecology and Obstetrics (FIGO) stages and histologic grade in the SATB1-high group vs the SATB1-low group. In the subgroup analysis of pathological types, a significantly higher SATB1 expression level was noted in adenocarcinomas group vs both the squamous cell carcinomas and adenosquamous carcinomas groups. Findings suggest expression of SATB1 to be correlated with disease progression and survival outcome of cervical cancer. Worse overall survival was seen in the SATB1-high group.
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