Lilis I, et al. - Researchers addressed the role of phosphorylated mTOR (p-mTOR) in prostate adenocarcinoma-induced lymphangiogenesis and lymph node metastasis. They also investigated its relationship with chicken ovalbumin upstream promoter transcriptional factor 2 (COUP-TFII) and the vascular endothelial growth factors A/C (VEGF A/C). Findings suggested the implication of increased p-mTOR and COUP-TFII expression in human prostate adenocarcinoma-induced lymphangiogenesis and lymph node (LN) metastasis. Increased expression of p-mTOR was positively associated with COUP-TFII expression in cancer cells.