Ramnarine VR, Kobelev M, Gibb EA, et al. - A systematic review was done using PubMed to look for reports with terms “long noncoding RNA”, “prostate”, and “cancer” over the past 30 yr (1988–2018) by the experts in order to review recent research investigating the functional biology of long noncoding RNAs (lncRNAs) in prostate cancer (PCa) over the past three decades. A historical timeline of lncRNA identification was defined, where each lncRNA was classified mechanistically and within the primary areas of carcinogenesis, ie, tumor risk and initiation, tumor promotion, tumor suppression, and tumor treatment resistance. Select lncRNAs that exemplify these areas were also defined. Whether these lncRNAs had a clinical utility in PCa diagnosis, prognosis, and prediction, and as therapeutic targets, was also analyzed. The biology of lncRNA was observed to be multifaceted, exhibiting a complex array of molecular and cellular functions. In every stage of PCa, the lncRNAs were involved. Their clinical utility for diagnosis, prognosis, and prognostication of PCa was well supported, but additional assessments for their therapeutic candidacy is required. Thus, detailed resource and view inside the lncRNA landscape for other cancer biologists, oncologists, and clinicians was given.