Sun Y, Liu J, Geng Z, et al. - This study was attempted to investigate serum calcineurin (CaN) and nuclear factor of activated T-cells 1(NFAT1) levels in patients with Kawasaki disease (KD). Researchers assessed serum levels of CaN and NFAT1 by enzyme-linked immunosorbent assay method in 66 healthy children and 74 KD individuals at acute, afebrile and subacute stage. The data indicated that the serum levels of CaN and NFAT1 raised significantly in the acute stage, and lowered progressively in the afebrile and subacute stage, along with the reduction of C-reactive protein, white blood cells and neutrophil counts. The expression of CaN and NFAT1 was upregulated significantly in KD individuals compared with that in the healthy control, in the acute stage, the afebrile stage and the subacute stage. It was showed that the serum levels of CaN and NFAT1 declined significantly in IVIG responders after the IVIG treatment.  The data showed that the specific regulation of CaN and NFAT1 serum levels in the course of KD was indicated that both of them were related in the development of KD.