Xing X, Chen L, Xu Z, et al. - Researchers conducted the study for analyzing the safety and effectiveness of 1.8% liposomal tranexamic acid (TA) and microneedling with 5% TA solution on melasma. Sixty patients with melasma were recruited and randomized to receive 1.8% liposomal TA twice daily, microneedling with 5% TA solution weekly or 2% hydroquinone every night. According to results, 27.8% of patients of liposomal TA group, 33.3% of microneedling with TA solution group, and 30.0% of hydroquinone group were recognized as “more than 50% improvement.” The authors concluded that 1.8% liposomal TA and microneedling with 5% TA solution are both effective and safe for melasma.