Shen S, et al. - Researchers investigated the efficacy and safety of methylprednisolone in the setting of postoperative pain after total knee arthroplasty (TKA) via performing a meta-analysis from randomized controlled trial (RCTs). Electronic searches of Medline (1966 to October 2017), Embase (1980 to October 2017), ScienceDirect (1985 to October 2017) and the Web of Science (1995 to October 2017) yielded 4 RCTs involving 248 patients for inclusion. Outcomes suggest a significant potential of methylprednisolone for alleviating postoperative pain score, narcotic consumption and opioid-related adverse effects after TKA.