Treesirichod A, Chuenboonngarm S, Kritsanaviparkporn C, et al. - Comparing topical 20% urea cream to 10% urea cream for acanthosis nigricans in adolescents, it was found that neck hyperpigmentation associated with the disease was improved by urea cream, with 20% concentration showing superior efficacy to the 10% concentration.

• This is a randomized comparative, double-blind study with 40 patients aged 12–18 years with acanthosis nigricans of the neck.

• Throughout 8 weeks of treatment, a greater improvement of hyperpigmentation was achieved with 20% urea than 10% urea, with 22.5 ± 11.9% and 10.7 ± 8.1% improvements, respectively.

• Results from the overall global evaluation scales were found to be consistent with the revelations from the narrowband reflectance spectrophotometer.

• Good tolerability of 10% urea and 20% urea was evident, without any local serious adverse reactions.