Ponce OJ, et al. - Researchers determined the efficacy and adverse events associated with testosterone replacement therapy (TRT) in symptomatic hypogonadal men. From inception to 2 March 2017, Ovid Medline, Ovid Embase, Ovid Cochrane Database of Systematic Reviews, Ovid Cochrane Central Register of Controlled Trials, and Scopus were searched. Findings revealed that TRT improves sexual desire, erectile function, and sexual satisfaction but not mood, energy, or cognition in hypogonadal men. It was noted that testosterone treatment increases the risk of erythrocytosis in hypogonadal men.