Ghorbani Z, Rafiee P, Fotouhi A, et al. - In view of the emerging evidence indicating promising effects of vitamin D on headaches characteristics, researchers undertook this research to further clarify the mechanisms by which this vitamin exerts anti-migraine effects. They performed a 16-week randomized double-blind placebo-controlled trial randomizing 80 episodic migraine patients in 2 parallel groups, each consisting of 40 patients, to receive vitamin D 2000 IU/d or placebo. Assessment of headache diaries and migraine disability assessment questionnaire, completed at baseline and following the intervention completion, and measurement of interictal serum concentration of CGRP (as the dominant mediator of migraine pain pathogenesis) led to the finding that there was an improvement in migraine headache characteristics and disability in correlation with vitamin D supplementation in episodic migraineurs, particularly in those with migraine with aura; this may probably through attenuating CGRP levels. This affords new insight into the anti-nociceptive effects of vitamin D.