Busby J, Khoo E, Pfeffer PE, et al. - Given that various studies have examined the physiological impact of OCS ( Oral corticosteroids) in stable asthma, but these have involved heterogeneous groups and results, therefore, their results were integrated for the first time ever via this analysis. Researchers analyzed 61 studies with 1,608 patients. The included studies were identified from Medline, Embase and Web of Science databases, and described the effect of OCS on FEV ₁, functional vital capacity, blood eosinophils, fractional exhaled nitric oxide, Asthma Control Questionnaire score or Asthma Quality Of Life Questionnaire score in stable asthma. As per findings, a consistent improvement of lung function, decline of markers of type-2 inflammation, and alleviation of asthma symptoms was afforded by treatment with OCS. However, after treatment, there was substantial residual impairment, and experts noted that mean improvements were below the minimally essential clinically difference. More response to treatment was evident in cases with increased markers of type-2 inflammation, indicating these should be used to better target OCS use.