Jamilian M, et al. - The effects of omega-3 and vitamin E co-supplementation were evaluated on parameters of mental health and gene expression related to insulin and inflammation in subjects with polycystic ovary syndrome (PCOS). In improving parameters of mental health, and gene expression of peroxisome proliferator-activated receptor gamma (PPAR-γ), interleukin-8 (IL-8) and tumor necrosis factor alpha (TNF-α) of women with PCOS, omega-3, and vitamin E co-supplementation were effective.