The effects of obstructive sleep apnea on risk factors for cardiovascular diseases
ENT Journal Nov 02, 2019
Jung JH, et al. - A total of 108 consecutive adult habitual snorers underwent polysomnography (PSG) and researchers investigated the association between PSG and risks factor for coronary heart disease in individuals suspected to have obstructive sleep apnea (OSA). In the control group (n = 21), mild (n = 29), moderate (n = 31), and severe (n = 27), the mean respiratory disturbance index (RDI) scores were 0.53, 10.6, 27.3, and 45.1, respectively. Partial correlation analysis exhibited that following adjustment for BMI, individuals’ RDI score was significantly related to CRP and the mean Epworth sleepiness scale (ESS) score related significantly to the CRP level. Partial correlation analysis exhibited that following adjustment for BMI Pearson’s correlation coefficients investigating the correlation between BMI and total cholesterol, the mean least oxygen saturation was significantly associated with CRP. The association of CRP levels with disease severity as evaluated via RDI, ESS, and least oxygen saturation was important following adjustment for BMI. Hence, individuals with OSA have raised serum levels of high-sensitivity-CRP which is a marker for inflammation and an independent risk predictor for cardiovascular morbidity.
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