Munugodaa IP, Beavers DP, Wirth W, et al. - Considering meniscus extrusion is correlated with knee pain, this research evaluated if weight loss by diet and/or exercise is correlated with less progression in meniscus extrusion measures over time. Researchers performed a prospective, single-blind, randomized controlled trial recruiting overweight and obese older adults with knee pain and radiographic osteoarthritis (OA). Individuals were assigned randomly to 18-month interventions: exercise only, diet only or diet+exercise. In a random subsample of 105 individuals, at baseline and follow-up, MRIs were obtained. The data indicated that there was an association between weight loss and less progression over time of medial meniscus extrusion as measured by the maximum and mean extrusion distances. There were no associations with weight loss for lateral meniscus position, medial or lateral meniscus size or semiquantitative measures. It was noted that weight loss was correlated with beneficial modifications of medial meniscus extrusion over 18 months. This may be one of the tools by which weight loss transposes into a clinical advantage.