Ismail NA, et al. - In this single-centre, prospective interventional study, the researchers sought to assess the impact of vitamin D treatment on clinical and biochemical outcomes of primary aldosteronism (PA), a condition caused by overproduction of aldosterone, patients. This investigation was conducted at the Hospital Canselor Tuanku Muhriz, National University of Malaysia Medical Centre, Kuala Lumpur. Two hundred and forty hypertensive individuals who attended the Endocrine Hypertension clinic from July till October 2018 were screened, 31 had positive aldosterone-renin-ratio, and 17 individuals with newly confirmed PA following positive confirmatory test that has not been subjected for definitive treatment were recruited. This investigation showed a significant proportion of patients with PA who have insufficient vitamin D. Treatment with vitamin D improves these interrelated parameters which may indicate the interplay between vitamin D, aldosterone, renal function, and blood pressure.