Raffin EP, et al. - Authors assessed the association between potassium citrate (Kcit) or thiazides and overall stone-related health-related quality of life (HRQOL). Findings demonstrated that among stone-formers an association of use of Kcit and thiazides with better HRQOL across all Wisconsin Stone Quality of Life questionnaire (WISQOL) domains was seen, without increased likelihood of GI complaints and of fatigue or sexual complaints, respectively. When counseling patients regarding initiation of Kcit or thiazides for medical management of nephrolithiasis, these findings may be useful.