Tsuboi M, et al. – As defined in the eighth edition of the TNM Classification (TNM8), the effect of tegafur–uracil (UFT) on survival in maximum primary tumor diameter (T) categories, was assessed. In these patients, the adjuvant chemotherapy with UFT tended to improve survival of each T category based on TNM8, except T1b.

Methods

• Based on the T category (TNM8), tumors were subgrouped as follows: T1a, T ≤1 cm; T1b, 1 < T ≤2 cm; T1c, 2 < T ≤3 cm; T2a, 3 < T ≤4 cm; T2b , 4 < T ≤5 cm; T3, 5 < T ≤7 cm.
• Cox proportional hazard models computed hazard ratios (HR) and 95% confidence intervals (CI). 

Results

• An association of UFT with improved survival, was observed.
• Moreover, following were the adjusted HRs: for T1a, 0.79 (95% CI 0.14-4.50); for T1b, 1.16 (95% CI 0.63-2.12); for T1c, 0.74 (95% CI 0.43-1.27); for T2a, 0.45 (95% CI 0.21-0.96); for T2b, 0.55 (95% CI 0.10-3.07), and for T3, 0.70 (95% CI 0.20-2.50).