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The effect of sex and menopause on carotid intima-media thickness and pulse wave velocity in morbid obesity

European Journal of Clinical Investigation May 10, 2019

van Mil SR, et al. - As morbid obesity is an independent risk factor for cardiovascular disease, researchers investigated if the correlation between sex and cardiovascular risk factors and outcomes are seen in those with morbid obesity. In a study of cardiovascular risk factors in morbid obesity, 200 participants underwent thorough laboratory screening, including measuring carotid intima-media thickness (cIMT) and pulse wave velocity (PWV). Using univariate and multivariable linear regression models, gender differences were analyzed. In those with morbid obesity, sex differences in PWV endured, though after adjusting for classic cardiovascular risk factors, cIMT did not differ between morbidly obese men and women. In comparison to postmenopausal morbidly obese women, premenopausal morbidly obese women are protected against cardiovascular disease.

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