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The effect of sevoflurane on the transmural dispersion of repolarisation in patients with type 2 diabetes mellitus: A prospective observational study

Anesthesia and Intensive Care Jan 26, 2018

Thiruvenkatarajan V, et al. - The ‘torsadogenic’ property of a drug is linked to its ability to increase the transmural dispersion of repolarisation, represented by the interval between the peak of, and the end of, the T-wave (Tp-e interval) in an electrocardiogram. Whether sevoflurane increases the Tp-e interval and Tp-e/QTc (rate-corrected QT interval) ratio in patients with diabetes, thereby increasing their risk of torsades, was ascertained in this current study. In the absence of other factors affecting ventricular repolarisation, no significant predictable pro-arrhythmic effect of sevoflurane was apparent in type 2 diabetic patients.
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