Pour FK, Aryaeian N, Mokhtare M, et al. - In this double‐blind randomized clinical trial, researchers, for the first time, sought to examine saffron intake effects on inflammation, oxidative stress, adipokines, anthropometric, and body composition in nonalcoholic fatty liver disease (NAFLD) patients. The sample consisted of 76 eligible men and female patients with NAFLD aged 18 to 65 years, selected from Hazrat Rasul Akram Hospital in Tehran, Iran. Participants in the study were assigned randomly to two groups receiving daily supplementation of either one tablet of 100 mg saffron (n = 38) or one placebo (n = 38) for 12 weeks. According to findings, 12 weeks of 100 mg of saffron supplementation suggested beneficial effects on serum levels of some inflammatory, oxidative stress, and adipokines biomarkers but did not significantly affect serum concentrations of liver enzymes, anthropometric, and body composition measurements.