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The effect of ovarian stimulation on endothelial function—A prospective cohort study using peripheral artery tonometry

Journal of Clinical Endocrinology & Metabolism Oct 16, 2020

Kirshenbaum M, Haas J, Nahum R, et al. - Researchers performed this prospective cohort study to compare the impact of different modes of final follicular maturation (hCG vs GnRH-a) following ovarian stimulation (OS) for in vitro fertilization (IVF) on endothelial function. This investigation was carried out at a tertiary medical center. According to the type of final follicle maturation, patients aged 37 years or younger undergoing OS for IVF were allocated into 2 groups: the hCG group (n = 7) or the GnRH-a group (n = 8). For all patients, the mean RHI values at day 0 were within the normal range and similar between the two groups (hCG: 1.7 ± 0.3 vs GnRH-a: 1.79 ± 0.4). Triggering final follicular maturation with GnRH-a restored normal endothelial function, while hCG trigger resulted in endothelial function decreased.

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