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The effect of omalizumab treatment on the low affinity immunoglobulin E receptor (CD23/fc epsilon RII) in patients with severe allergic asthma

Allergy and Asthma Proceedings Jan 06, 2018

Assayag M, et al. - This inquiry was set up to investigate if CD23 plays a role in the inflammatory process in severe uncontrolled asthma and if anti-immunoglobulin E (IgE) therapy modulates fc epsilon RII/CD23 expression in these patients. Findings demonstrated that in severe asthma, modulation of the low affinity IgE receptor CD23 was complex and disease activity may be inversely indicated by soluble CD23 (sCD23). In addition, reduced monocyte activation was observed in association with treatment with omalizumab.
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