Crimi E, et al. - Researchers performed this prospective study to determine the impact of using modified ultrafiltration at the end of cardiopulmonary bypass for cardiac surgical procedures on vancomycin serum concentrations in 26 elective adult patients undergoing cardiac surgery with cardiopulmonary bypass from April 2014 to April 2015. They found that, serum vancomycin levels did decrease significantly but not to a clinically relevant amount, by using modified ultrafiltration at the end of cardiopulmonary bypass. Compared to the minimum inhibitory concentration for Staphylococcus epidermidis and Staphylococcus aureus, the observed decrease was still significantly higher; therefore, additional vancomycin administration was not recommended.