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The effect of maternal age on cardiac adaptation in pregnancy

Ultrasound in Obstetrics & Gynecology Feb 21, 2021

Ling HZ, Jara PG, Nicolaides KH, et al. - Researchers conducted this prospective, longitudinal study with the aim to compare the longitudinal maternal hemodynamic changes throughout gestation between different age groups. Maternal hemodynamics were assessed at 11 +0 ‐13 +6 , 19 +0 ‐24 +0 , 30 +0 ‐34 +0 and 35 +0 ‐37 +0 weeks’ gestation. According to maternal age at the first visit at 11 +0 ‐13 +6 weeks, they divided women into four groups: Group 1 < 25 years (n = 254); group 2, 25‐30 years (n = 442), group 3, 30.1‐34.9 years (n = 618) and group 4, ≥ 35 years (n = 475). Findings revealed the highest cardiac output (CO) and lowest peripheral vascular resistance (PVR) throughout pregnancy in younger women (group 1) and the lowest CO and highest PVR throughout pregnancy among older women (group 4). The youngest age group had the highest incidence of SGA neonates despite demonstrating an apparently more favourable hemodynamic profile. Overall findings suggest that the differences in birth of SGA neonates between age groups could not be explained by the age‐specific differences in maternal hemodynamic adaptation.

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