Noronha JC, et al. - In overweight/obese people with type 2 diabetes, researchers synthesized the evidence of the effect of liquid meal replacements on cardiometabolic risk factors via searching MEDLINE, EMBASE, and the Cochrane Library through 10 December 2018. Using GRADE (Grading of Recommendations Assessment, Development and Evaluation), the overall certainty of the evidence was evaluated. According to findings, liquid meal replacements in weight loss diets result in modest declines in body weight, BMI, and systolic blood pressure, and reductions of marginal clinical significance in body fat, waist circumference, HbA_1c, fasting glucose, fasting insulin, and diastolic blood pressure. No effect on blood lipids was found. Due to imprecision and/or inconsistency, the overall certainty of the evidence was low to moderate.