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The effect of ketogenic diet on serum lipid concentrations in children with drug resistant epilepsy

Seizure - European Journal of Epilepsy Jun 13, 2021

Yılmaz U, Edizer S, Köse M, et al. - Researchers conducted the study for examining the long-term impacts of the ketogenic diet (KD) on serum lipid concentrations in children with medication-resistant epilepsy in daily clinical practice. In total, 73 children (40 girls) aged 3 to 193 months (median, 53 months) with medication-resistant epilepsy who received a KD treatment for at least 12 months between 2014 and 2019 years were registered in the investigation. All children were started on a KD with a 3:1 ratio, which was then adjusted between 2:1 and 4:1 as clinically necessary after the onset of KD. At 1, 6, 12, 18, and 24 months, 71.2, 63, 63, 50, and 52.5% of the patients had dyslipidemia, respectively. Total cholesterol and triglyceride concentrations seem to rise during the first month of KD treatment, and while these high levels persist for 24 months, the rise does not continue; rather, it approaches normal levels by drawing a downward trend. However, cholesterol and triglyceride levels do not rise in the subset of patients who already have dyslipidemia.

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