Obradovic M, Kurz A, Kabon B, et al. - This inquiry was performed among patients undergoing moderate- to high-risk open abdominal surgery, to investigate whether a goal-directed colloid regimen reduces the inflammatory response vs a goal-directed crystalloid regime. The participants were randomized to goal-directed lactated Ringer’s solution (n = 58) or a hydroxyethyl starch 6% 130/0.4 (n = 62) fluid regimen. Perioperative concentrations of pro- and anti-inflammatory cytokines were assessed (primary outcome). Findings demonstrated no difference in cytokine and inflammatory marker levels between goal-directed crystalloid and colloid administration following moderate to high-risk abdominal surgery.