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The effect of food on the pharmacokinetics of niraparib, a poly(ADP-ribose) polymerase (PARP) inhibitor, in patients with recurrent ovarian cancer

Cancer Chemotherapy and Pharmacology Jan 14, 2018

Moore K, et al. - Researchers conduct this open-label crossover study to evaluate the effects of food on niraparib pharmacokinetics (PK) and safety in patients with recurrent ovarian cancer. Observations reveal no impact of a high-fat meal on the PK profile of niraparib, suggesting that niraparib can be taken with or without food. Niraparib is demonstrated to be safe and well-tolerated.
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