Malhotra R, et al. - Short-term studies have suggested that niacin lowers serum phosphate concentrations in patients with CKD and ESRD. In this current study, researchers investigated the long-term effects of niacin, relative to placebo, on serum phosphate and other mineral markers in participants with eGFR<60 ml/min per 1.73 m². Lowered serum phosphorous concentrations were reported as a result of using niacin over 3 years but no impact was seen on other markers of mineral metabolism in CKD patients.