Aboulghar MM, El-Faissal Y, Kamel A, et al. - Researchers aimed at determining the effect of earlier administration of natural progesterone, in IVF/ICSI twin pregnancies starting at 11–14 weeks for prevention of preterm birth. In this double-blind, placebo controlled, single center, randomized clinical trial, they randomized women with dichorionic twin gestations, having an IVF/ICSI trial to receive either natural rectal progesterone (800 mg daily) or placebo, starting early from 11 to 14 weeks. In addition, the women were administered oral and vaginal antimicrobial agents as part of routine treatment for vaginitis and urinary tract infection. Outcomes revealed no reduction in spontaneous preterm birth in correlation with receiving rectal natural progesterone starting from the first trimester in IVF/ICSI twin pregnancies.