Serrano E, et al. - Given a number of observational studies quantifying the negative effect of cirrhosis on mortality following traumatic injury, researchers here sought to ascertain the magnitude of the effect of liver cirrhosis on mortality, morbidity, and hospital course among trauma patients. In addition, they analyzed sources of study heterogeneity that may result in disparities in estimates in the observed mortality rate among patients with cirrhosis. Searching EMBASE and PubMed systematically, they reviewed title and abstract of 15,958 articles leading to the identification of 31 relevant articles. This meta-analysis ultimately included 18 observational studies. Outcomes revealed association of preexisting liver cirrhosis with increased mortality rate, complication rate, and length of hospitalization among trauma patients, even after adjusting for confounding factors and potential sources of between-study heterogeneity. Heightened surveillance and injury prevention interventions may benefit trauma patients with cirrhosis.