Duggal V, et al. - In this multicenter, single-blinded, randomized, parallel-design controlled trial, researchers assessed dialysis recovery time (DRT) in relation to blood flow rate reduction vs usual care. Participants were 102 end-stage renal disease patients receiving maintenance hemodialysis in 18 centers with baseline DRT of greater than 6 hours. As an intervention, blood flow rate reduction of 100 mL/min, to a minimum of 300 mL/min was implemented. In controls and in the intervention group, the baseline median DRT was 720 minutes and 720 minutes, respectively. Compared with usual care, no superior improvement in DRT was reported in relation to blood flow rate reduction. To address patient-reported fatigue, although there is a requirement for more work to be done, a significant positive influence could not be achieved without substantial alterations in dialysis prescription.