Tickell KD, et al. - This study was undertaken to analyze whether acute malnutrition modifies the correlation between common enteric pathogens and moderate-to-severe diarrhoea and whether associations between enteric pathogens and death were modified by acute malnutrition. In this post-hoc analysis, they enrolled children with moderate-to-severe diarrhoea and age-matched and community-matched controls. They examined whether acute malnutrition modified relationships between enteric pathogens and moderate-to-severe diarrhoea in conditional logistic regression models. They applied Cox proportional hazards regression to evaluate the modifying effect of acute malnutrition on the relationship between pathogens and 60-day fatality rate among children with moderate-to-severe diarrhoea. They indicated that acute malnutrition might establish relationships between specific pathogens and moderate-to-severe diarrhoea. Nevertheless, in children, the strong relationship between acute malnutrition and mortality during moderate-to-severe diarrhoea is not limited to specific infections and influences a broad spectrum of enteric pathogens.