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The ED50 and ED95 of oxytocin infusion rate for maintaining uterine tone during elective caesarean delivery: A dose-finding study

BMC Pregnancy and Childbirth Jan 08, 2020

Qian, XW, et al. - As per previous works, the 90% effective dose (ED90) of oxytocin infusion is estimated as 16.2 IU h− 1. However, as the infusion dose required decreased with bolus administration of oxytocin prior to the infusion, researchers sought to determine the ED95 for oxytocin infusion after a bolus at elective cesarean delivery (CD) in nonlaboring parturients. In this randomized, triple blinded study, they randomized 150 healthy termparturients scheduled for elective CD under epidural anesthesia, following delivery of the infant and i.v. administration of 1 IU oxytocin as a bolus, to receive oxytocin infusion at a rate of 0, 1, 2, 3, 5, or 8 IU h− 1, for a total of 1 h. As per outcomes, an infusion rate of oxytocin at 7.72 IU h− 1 may lead to the production of adequate uterine tone in 95% of parturients receiving a 1 IU bolus of oxytocin during elective cesarean delivery. Results thereby suggest that a reduction in the total dose of oxytocin administered in the postpartum period could be done when offered as an infusion after oxytocin bolus.
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