O'Malley EG, Reynolds CME, O'Kelly R, et al. - In this prospective study, researchers sought to compare different sets of diagnostic cut-off points for plasma glucose measurements following a 75 g oral glucose tolerance test (OGTT). Women who had maternal risk factors for gestational diabetes mellitus (GDM) were selected at their convenience during their first prenatal visit and accepted a one-step OGTT at 26–28 weeks of gestation. All women who met the diagnostic requirements of the World Health Organization (WHO) in 2013 received standard care for GDM. Of the 202 women, 139 (69%) had one GDM risk factor and 63 (31%) had > 1. Under strict research conditions, findings indicate that the Canadian and, in particular, the NICE criteria do not identify women who may benefit from improved glycaemic control. Such outcomes supported the need for a planned review of the NICE guidelines on GDM in 2020.