Yanai H, Levine A, Hirsch A, et al. - In adults suffering from mild-to-moderate biologic naïve Crohn disease, CDED (Crohn disease exclusion diet) with or without partial enteral nutrition showed effectiveness for induction as well as maintenance of remission and might result in endoscopic remission. According to findings, CDED could be employed for mild-to-moderate active Crohn's disease.

• An open-label, pilot randomized trial of adults with Crohn's disease who were randomly assigned (n=44) (1:1) to CDED plus partial enteral nutrition or CDED alone for 24 weeks.

• At week 6, clinical remission was achieved by 68% of patients in the CDED plus partial enteral nutrition group and by 57% of patients in the CDED group.

• Among the 25 patients in remission at week 6, 80% (n=20) were in sustained remission at week 24 (12 in the CDED plus partial enteral nutrition group and 8 in the CDED alone group).

• At week 24, 35% were in endoscopic remission (n=14/40) (8 in the CDED plus partial enteral nutrition group and 6 in the CDED alone group).

• In both groups, no serious adverse events or treatment-related adverse events occurred.