Kip MMA, et al. – Here, the authors examine the potential cost–utility of diagnosing acute coronary syndrome (ACS) by a general practitioner (GP) when a point–of–care (POC) troponin test is available versus GP assessment only. By reducing hospital referrals, the POC troponin strategy is likely cost–saving. In this analysis, the small increase in missed ACS patients can be partly explained by conservative assumptions used. Moreover, current developments in POC troponin tests will likely further improve their diagnostic performance. Hence, to examine whether those developments make the POC troponin test to a safe and cost–effective diagnostic tool for diagnosing ACS in general practices, future prospective studies are warranted.