Samuelson EM, Ebel JA, Reynolds SB, et al. - Researchers evaluated a series (total of 3 injections) of intra-articular platelet-rich plasma (PRP) injections, in terms of cost-effectiveness, relative to that of hyaluronic acid (HA) viscosupplementation for the management of symptomatic knee osteoarthritis. Relevant data were obtained from the highest-quality data (Level I) available in the literature until 2015. Findings revealed that cost-effectiveness of PRP injections was not more than that of HA injections, although a series of either PRP [$8,635.23/QALY (quality-adjusted life-year)] or HA ($5,331.75/QALY) injections for the management of symptomatic knee osteoarthritis would be regarded as cost-effective (cost per QALY < $50,000). Significantly greater effectiveness of PRP was, however, evident at 1 year, and an incremental cost-effectiveness ratio of $12,628.15/QALY was reported in relation to PRP vs HA, therefore, experts recommended considering a series of PRP injections as a reasonable and acceptable alternative to HA injections for the treatment of symptomatic knee osteoarthritis.