Tang M, Liu PJ, Yue B, et al. - Researchers investigated whether the expression of mutant p53 protein was correlated with cellular atypia in early differentiated gastric adenocarcinoma (DGA). From the Pathology Department of Beijing Friendship Hospital, 107 cases of early DGA samples resected by endoscopic submucosal dissection were obtained. Findings showed a close correlation of mutant p53 protein expression with cell atypia. The results demonstrated high expression of mutant p53 protein in early DGA, which can be employed as an auxiliary index for the diagnosis of early gastric cancer. Experts noted that mutant p53 protein had different expression patterns in high-grade and low-grade atypical gastric cancers; this indicates that these may have different genetic alterations.