Chen C, Dong H, Shou C, et al. - Whether computer tomography (CT) volumetry affords a feasible and useful method to assess tumor response to neoadjuvant chemotherapy (NAC) in advanced gastric cancer (AGC) patients, was determined in this study among patients (n = 117) with AGC who were treated with NAC followed by R0 resection between January 2006 and December 2012. Researchers calculated the volume reduction rate (VRR) as follows: VRR = [(pre-chemotherapy total volume) − (post-chemotherapy total volume)]/(pre-chemotherapy total volume) × 100%. As per ROC analysis, the optimal cut-off VRR was estimated to be 31.95%, with a sensitivity and specificity of 70.4% and 71.7%, respectively. Two groups were defined on the basis of the cut-off VRR: VRR-High (VRR ≥ 31.95%, n = 63) and VRR-Low (VRR < 31.95%, n = 54) groups. A worse prognosis was seen in the VRR-Low group vs VRR-High group. In the VRR-Low group and VRR-High group, 3-year survival rates were reported to be 40.7% and 79.4%, and 5-year survival rates were 31.5% and 63.5%, respectively. Overall, findings revealed the feasibility as well as the reliability of CT volumetry as a method for evaluating the tumor response to NAC in patients with AGC.